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Publications

1. Cunningham CC, Vegners R, Bucki R, Funaki M, Korde N, Hartwig JH, Stossel TP, Janmey PA. Cell permeant polyphosphoinositide-binding peptides that block cell motility and actin assembly.  J Biol Chem. 2001 Nov 16; 276(46): 43390-9.

2. Funaki M, Randhawa P, Janmey P.  Separation of Insulin Signaling into Distinct GLUT4 Translocation & Activation Steps. Mol Cell Biol. 2004 Sep;24(17):7567-77.

3. Yeung T, Georges PC, Flanagan L, Marg B, Ortiz M, Funaki M, Zahir N, Ming M, Weaver V, Janmey PA.  Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion.  Cell Motil Cytoskeleton. 2004 Nov 30;60(1):24-34

4. Sasaoka T, Fukui K, Wada T, Murakami S, Kawahara J, Ishihara H, Funaki M, Asano T, Kobayashi M.  Inhibition of endogenous SHIP2 ameliorates insulin resistance caused by chronic insulin treatment in 3T3-L1 adipocytes.  Diabetologia. 2005 Jan 15 ;48(2):336-44

5. Funaki M, DiFransico L, Janmey PA.  PI 4,5-P2 stimulates glucose transport
activity of GLUT4 in the plasma membrane of 3T3-L1 adipocytes.  Biochim Biophys Acta.  2006 Aug;1763(8):889-99.

6. Funaki M, Benincasa K, Randhawa PK.  Peptide rescues GLUT4 recruitment, but not
GLUT4 activation, in insulin resistance.  Biochem Biophys Res Commun. 2007 Sep 7;360(4):891-6. Epub 2007 Jul 6

7. Winer JP, Janmey PA, McCormick ME, Funaki M. Bone marrow-derived human mesenchymal stem cells become quiescent on soft substrates but remain responsive to chemical or mechanical stimuli. Biosci Biotechnol Biochem. 2008 Mar;72(3):773-7. Epub 2008 Mar 7.

8. Li Q, Hosaka T, Jambaldorj B, Nakaya Y, Funaki M. Extracellular matrix with the rigidity of adipose tissue helps 3T3-L1 adipocytes maintain insulin responsiveness. J Med Invest. 2009 Aug;56(3-4):142-9.

9. Li Q, Yin W, Cai M, Liu Y, Hou H, Shen Q, Zhang C, Xiao J, Hu X, Wu Q, Funaki M, Nakaya Y. NO-1886 suppresses diet-induced insulin resistance and cholesterol accumulation through STAT5-dependent upregulation of IGF1 and CYP7A1. J Endocrinol. 2010 Jan;204(1):47-56. Epub 2009 Oct 8.

10. Chung le TK, Hosaka T, Harada N, Jambaldorj B, Fukunaga K, Nishiwaki Y, Teshigawara K, Sakai T, Nakaya Y, Funaki M. Myosin IIA participates in docking of Glut4 storage vesicles with the plasma membrane in 3T3-L1 adipocytes. Biochem Biophys Res Commun. 2010 Jan 1;391(1):995-9. Epub 2009 Dec 5.

11. Li Q, Hata A, Kosugi C, Kataoka N, Funaki M. The density of extracellular matrix proteins regulates inflammation and insulin signaling in adipocytes. FEBS Lett. 2010 Oct 8;584(19):4145-50.

12. Li Q, Hosaka T, Shikama Y, Bando Y, Kosugi C, Kataoka N, Nakaya Y, Funaki M. Heparin-binding EGF-like growth factor (HB-EGF) mediates 5-HT-induced insulin resistance through activation of EGF receptor-ERK1/2-mTOR pathway. Endocrinology. 2012 Jan;153(1):56-68.

13. Li Q, Hosaka T, Harada N, Nakaya Y, Funaki M. Activation of Akt through 5-HT2A receptor ameliorates serotonin-induced degradation of insulin receptor substrate-1 in adipocytes. Mol Cell Endocrinol. 2013 Jan 5;365(1):25-35. doi: 10.1016/j.mce.2012.08.022. Epub 2012 Sep 10.

14. Nobuhara M, Saotome M, Watanabe T, Urushida T, Katoh H, Satoh H, Funaki M, Hayashi H.  Mitochondrial dysfunction caused by saturated fatty acid loading induces myocardial insulin-resistance in differentiated H9c2 myocytes: a novel ex vivo myocardial insulin-resistance model.  Exp Cell Res. 2013 Apr 15;319(7):955-66.

15. Umeno A, Shichiri M, Ishida N, Hashimoto Y, Abe K, Kataoka M, Yoshino K, Hagihara Y, Aki N, Funaki M, Asada Y, Yoshida Y.  Singlet oxygen induced products of linoleates, 10- and 12-(Z,E)-hydroxyoctadecadienoic acids (HODE), can be potential biomarkers for early detection of type 2 diabetes.  PLoS One. 2013 May 15;8(5):e63542.

16. Shikama Y, Ishimaru N, Kudo Y, Bando Y, Aki N, Hayashi Y, Funaki M. Effects of free fatty acids on human salivary gland epithelial cells. J Dent Res. 2013 Jun;92(6):540-6. doi: 10.1177/0022034513487378. Epub 2013 Apr 19.

17. Jambaldorj B, Terada E, Hosaka T, Kishuku Y, Tomioka Y, Iwashima K, Hirata Y, Teshigawara K, Thi Kim Le C, Nakagawa T, Harada N, Sakai T, Sakaue H, Matsumoto T, Funaki M, Takahashi A, Nakaya Y. Cysteine string protein 1 (CSP1) modulates insulin sensitivity by attenuating glucose transporter 4 (GLUT4) vesicle docking with the plasma membrane. J Med Invest. 2013;60(3-4):197-204.

18. Hata A, Doi Y, Ninomiya T, Mukai N, Hirakawa Y, Hata J, Ozawa M, Uchida K, Shirota T, Kitazono T, Kiyohara Y. Magnesium intake decreases Type 2 diabetes risk through the improvement of insulin resistance and inflammation: the Hisayama Study. Diabet Med. 2013 Dec;30(12):1487-94. doi: 10.1111/dme.12250. Epub 2013 Jun 29.

19. Watanabe T, Saotome M, Nobuhara M, Sakamoto A, Urushida T, Katoh H, Satoh H, Funaki M, Hayashi H. Roles of mitochondrial fragmentation and reactive oxygen species in mitochondrial dysfunction and myocardial insulin resistance. Exp Cell Res. 2014 May 1;323(2):314-25. doi: 10.1016/j.yexcr.2014.02.027. Epub 2014 Mar 11.

20. Jin QR, Bando Y, Miyawaki K, Shikama Y, Kosugi C, Aki N, Funaki M, Noji S. Correlation of fibroblast growth factor 21 serum levels with metabolic parameters in Japanese subjects. J Med Invest. 2014;61(1.2):28-34

21. Kinouchi M, Aihara KI, Fujinaka Y, Yoshida S, Ooguro Y, Kurahashi K, Kondo T, Aki N, Kuroda A, Endo I, Matsuhisa M, Matsumoto T. Diabetic Conditions Differentially Affect the Endothelial Function, Arterial Stiffness and Carotid Atherosclerosis. J Atheroscler Thromb. 2014;21(5):486-500.

22. Naujok O, Bandou Y, Shikama Y, Funaki M, Lenzen S.  Effect of substrate rigidity in tissue culture on the function of insulin-secreting INS-1E cells.  J Tissue Eng Regen Med. 2014 Jan 8. doi: 10.1002/term.1857. [Epub ahead of print]

23. Shikama Y, Aki N, Hata A, Nishimura M, Oyadomari S, Funaki M. Palmitate-stimulated monocytes induce adhesion molecule expression in endothelial cells via IL-1 signaling pathway. J Cell Physiol. 2015 Mar;230(3):732-42. doi: 10.1002/jcp.24797.

24. Hata A, Yonemoto K, Shikama Y, Aki N, Kosugi C, Tamura A, Ichihara T, Minagawa T, Kuwamura Y, Miyoshi M, Nakao T, Funaki M. Cut-off value of total adiponectin for managing risk of developing metabolic syndrome in male Japanese workers. PLoS One. 2015 Feb 23;10(2):e0118373. doi: 10.1371/journal.pone.0118373. eCollection 2015.

25. Shikama Y, Kudo Y, Ishimaru N, Funaki M. Possible Involvement of Palmitate in Pathogenesis of Periodontitis. J Cell Physiol. 2015 Apr 29. doi: 10.1002/jcp.25029. [Epub ahead of print]   

26. Kido J, Bando Y, Bando M, Kajiura Y, Hiroshima Y, Inagaki Y, Murata H, Ikuta T, Kido R, Naruishi K, Funaki M, Nagata T. YKL-40 level in gingival crevicular fluid from patients with periodontitis and type 2 diabetes. Oral Dis. 2015 Jul;21(5):667-73. doi: 10.1111/odi.12334. Epub 2015 Apr 6. 

27. Shikama Y, Kudo Y, Ishimaru N, Funaki M. Possible Involvement of Palmitate in Pathogenesis of Periodontitis. J Cell Physiol. 2015 Dec;230(12):2981-9. doi: 10.1002/jcp.25029. 

28. Shikama Y, Kudo Y, Ishimaru N, Funaki M. Potential Role of Free Fatty Acids in the Pathogenesis of Periodontitis and Primary Sjögren's Syndrome. Int J Mol Sci. 2017 Apr 14;18(4). pii: E836. doi: 10.3390/ijms18040836. Review.

29.Xiaolin Y, Nakamoto M, Shuto E, Hata A, Aki N, Shikama Y, Bandou Y, Ichihara T, Minagawa T, Kuwamura Y, Tamura A, Uemura H, Arisawa K, Funaki M, Sakai T. Associations between intake of dietary fermented soy food and concentrations of inflammatory markers: a cross-sectional study in Japanese workers. The Journal of Medical Investigation 2018: 65(1-2): 74-80.

30.Nakamoto M, Shuto E, Nakamoto A, Hata A, Aki N, Shikama S, Bandou Y, Ichihara T, Minagawa T, Tamura A, Kuwamura Y, Funaki M, Sakai T. Soy product and isoflavone intake associations with allergic diseases in Japanese workers: rhinitis, dermatitis and asthma. Asia Pac J Clin Nutr  2018: 27(6):1277-1285. DOI: 10.6133/apjcn.201811_27(6).0015

31.Mori H, Kuroda A, Ishizu M, Ohishi M, Takashi Y, Otsuka Y, Taniguchi S, Tamaki M, Kurahashi K, Yoshida S, Endo I, Aihara K, Funaki M, Akehi Y, Matsuhisa M. Association of accumulated advanced glycation end-products with a high prevalence of sarcopenia and dynapenia in patients with type 2 diabetes. J Diabetes Investig, 2019 Sep;10(5):1332-1340. DOI: 10.1111/jdi.13014